Here are the possible solutions for best man's opening clue
Answer
Clue
Relevancy
atoast
Clue
Best man's opening
hairspray
Clue
It won the 2003 Tonys for Best Musical, Best Book, and Best Score
Definition
lacquer sprayed on the hair to hold it in place
groom
Clue
Best man's best friend, often
Definition
to clean and care for
gigli
Clue
2003 bomb imdb.com described as "The violent story about how a criminal lesbian, a tough-guy hit-man with a heart of gold, and a mentally challenged man came to be best friends through a hostage"