Crossword puzzle clue "cause total protonic reversal according to ghostbusters or what happens literally four times in this puzzle"

Cause "total protonic reversal," according to "Ghostbusters"...or what happens literally four times in this puzzle

River phenomena (or what literally happens six times in this puzzle)

It happens four times a year ... and also in this puzzle's circles

Director of "Ghostbusters" and "Ghostbusters II"

Certain filings, and what happens literally in six of this puzzle's answers

Ironic change in destiny ... and, literally, what happens in this puzzle's circles

Drawing tool literally represented four times in this puzzle?

"For his contributions to jazz, ___ should be smeared with bacon grease, placed in a cage with three underfed Kodiak grizzly bears, and whatever happens, happens." ("Genius Guide to Jazz")