Crossword puzzle clue "drug that's a downer"

Here are the possible solutions for drug that's a downer clue

Answer
Clue
Relevancy
opiate
Clue
Drug that's a downer
Definition
to treat with opium
trank
Clue
Downer drug, slangily
czar
Clue
Drug ___ (federal drug policy overseer)
Drug ___ (federal spokesperson on drug policy)
Drug ___ (federal drug-control boss)
Drug ___ (federal drug policy spokesperson)
Definition
(Russian) an emperor or king, also TSAR, TZAR, KSAR
ace
Clue
Plane downer
Definition
an expert
adamsapple
Clue
Throat's up-and-downer

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