Crossword puzzle clue "extremely significant"

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Here are the possible solutions for extremely significant clue

Answer
Clue
Relevancy
epochal
Clue
Extremely significant
Definition
belonging to an epoch; of the nature of an epoch
adam
Clue
Eve's significant other
agony
Clue
Significant suffering
Definition
extreme suffering
ahem
Clue
Significant cough.
Definition
a sound expressing delicate interruption
alone
Clue
Forever ___ (meme for people who will *never* have a significant other as long as they live)
Definition
solitary, apart from others
alot
Clue
Significant amount
alteregos
Clue
Significant others?
amie
Clue
Pierre's significant other
Definition
(French) a (female) friend

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