Here are the possible solutions for first of 22 letters clue
Answer
Clue
Relevancy
wcin
Clue
Radio station whose call letters include the first three letters of its Ohio city
arsene
Clue
Premier League manager Wenger (the club he manages has the same first five letters as his first name)
treadway
Clue
TV host whose first name is spelled by the first and last letters of his surname
fun
Clue
First word across in the first-ever crossword (1913) and the first of a dozen appearances of the word in this puzzle's grid, written word search-style (left, right, down, and diagonally) ... Can you f