Here are the possible solutions for first word of many a letter clue
Answer
Clue
Relevancy
fun
Clue
First word across in the first-ever crossword (1913) and the first of a dozen appearances of the word in this puzzle's grid, written word search-style (left, right, down, and diagonally) ... Can you f
Definition
to act playfully
dear
Clue
First word of many a letter
Definition
costly
psi
Clue
Greek letter whose first letter is silent
Definition
a Greek letter
isfor
Clue
Words between a letter and a word starting with that letter
plural
Clue
Word form made with the big letter depicted in this puzzle's diagram (this letter is entirely absent from the solution)
Definition
more than one
cara
Clue
Opening word of many an Italian letter
leadinglady
Clue
Star with many lines, or what the three-letter word at the beginning of each starred answer may be considered?