Crossword puzzle clue "fundamental defect"

to make defective or imperfect

a disorder of the blood, also ANAEMIA

a defect in the eye or a lens by which rays from a single source are not focused at a single point, also ASTIGMIA

of or pertaining to an atrium, a square hall lighted from above, into which rooms open at one or more levels

to mar

to annoy

to fill up cracks