Crossword puzzle clue "have a major reaction"

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Answer
Clue
Relevancy
salute
Clue
Have a major reaction?
Have a general reaction?
joetorre
Clue
First major league manager to have 2000 wins and have 2000 hits
edwardgrobinson
Clue
Actor who said "Some people have youth, some have beauty—I have menace"
ews
Clue
Sounds you might make when I say "Would you rather watch your parents have sex or have your parents watch you have sex?"
drool
Clue
Have a hungry reaction
Definition
to let saliva flow from the mouth
salivate
Clue
Have a mouthwatering reaction
sayno
Clue
Have a negative reaction

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