Crossword puzzle clue "having had it with up"

Like either option in "Would you rather watch a video of your parents having sex or your parents watch a video of you having sex?"

Show evidence of having had a difficult day?

Having had too much to drink

Having had it, with "up"

Having had way too many

Having had many birthdays

___ empty stomach (having not had a recent meal): 2 wds.

Having had enough