Crossword puzzle clue "most significant"

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Here are the possible solutions for most significant clue

Answer
Clue
Relevancy
greatest
Clue
Most significant
Definition
the greatest person in some field
main
Clue
Most significant
Definition
chief, principal
mainclaimtofame
Clue
Most significant entitlement
tetris
Clue
"The most-played, most-imitated, most influential puzzler of all time," per the video game website IGN
adam
Clue
Eve's significant other
agony
Clue
Significant suffering
Definition
extreme suffering
ahem
Clue
Significant cough.
Definition
a sound expressing delicate interruption
alone
Clue
Forever ___ (meme for people who will *never* have a significant other as long as they live)
Definition
solitary, apart from others

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