Crossword puzzle clue "notably significant"

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Here are the possible solutions for notably significant clue

Answer
Clue
Relevancy
salient
Clue
Notably significant
adam
Clue
Eve's significant other
agony
Clue
Significant suffering
Definition
extreme suffering
ahem
Clue
Significant cough.
Definition
a sound expressing delicate interruption
alone
Clue
Forever ___ (meme for people who will *never* have a significant other as long as they live)
Definition
solitary, apart from others
alot
Clue
Significant amount
alteregos
Clue
Significant others?
amie
Clue
Pierre's significant other
Definition
(French) a (female) friend

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