Here are the possible solutions for popular afternoon host clue
Answer
Clue
Relevancy
oprah
Clue
Popular afternoon host
ellen
Clue
Popular afternoon talk show, familiarly, and a homophonic hint to this puzzle's four longest answers
Popular afternoon talk show
teafortwo
Clue
Popular 1925 song (for afternoon drinking companions?)
donp
Clue
Outspoken "CNN Tonight" host ... or outspoken "Hockey Night in Canada" host, whomever is more to your taste
ian
Clue
Michael ___ Black ("Trust Me, I'm a Game Show Host" game show host)
jasonsklar
Clue
Comedian/former ESPN host whose twin brother Randy is also a comedian/former ESPN host
mixingitup
Clue
Host: "Well, that's because it's an anagram of your name. I guess it gives new meaning to the phrase '___'!" Flay: "Wait ... what?" Host: (Ding!) "And there's the timer! Tune in tomorrow for another t
