Crossword puzzle clue "significant effect"

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Here are the possible solutions for significant effect clue

Answer
Clue
Relevancy
impact
Clue
Significant effect
Definition
to fix firmly together
cause
Clue
Effect, or effect's partner
Definition
to bring about
nausea
Clue
Side effect or ride effect?
Definition
an inclination to vomit
adam
Clue
Eve's significant other
agony
Clue
Significant suffering
Definition
extreme suffering
ahem
Clue
Significant cough.
Definition
a sound expressing delicate interruption
alone
Clue
Forever ___ (meme for people who will *never* have a significant other as long as they live)
Definition
solitary, apart from others
alot
Clue
Significant amount

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