Crossword puzzle clue "significant suffering"

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Here are the possible solutions for significant suffering clue

Answer
Clue
Relevancy
agony
Clue
Significant suffering
Definition
extreme suffering
abad
Clue
In ___ way (suffering)
In --- way (suffering)
ache
Clue
Suffix for suffering body parts
Definition
to endure a dull lasting pain, also AKE
achierarchie
Clue
Griffin suffering more pain?
achy
Clue
Suffering from too much exercise
Suffering from a workout
Definition
aching
afflict
Clue
Cause suffering
Definition
to distress severely

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