Crossword puzzle clue "there's no gain without it"

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Answer
Clue
Relevancy
pain
Clue
There's no gain without it
Definition
to cause suffering or distress
amap
Clue
Answer to the riddle "What has rivers without water, forests without trees, and cities without houses?"
echo
Clue
"Anybody there? . . . there? . . . there?"
Definition
a reflected sound
isno
Clue
"There ___ there there"
"There ___ there there" (Gertrude Stein comment on Oakland)
"There ___ there there" (Gertrude Stein)
oakland
Clue
City about which Gertrude Stein said, "There is no 'there' there"
City about which Gertrude Stein said "There is no there there"

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