Crossword puzzle clue "took effect fragment"

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Answer
Clue
Relevancy
bit
Clue
Took effect — fragment
Definition
to curb or restrain
cause
Clue
Effect, or effect's partner
Definition
to bring about
nausea
Clue
Side effect or ride effect?
Definition
an inclination to vomit
medicare
Clue
Governmental health insurance program that took effect in 1966
Definition
a type of governmental health program, also MEDICAID
nafta
Clue
It took effect on Jan. 1, 1994
setin
Clue
Took effect
told
Clue
Took effect
Took effect.

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