Here are the possible solutions for your sister's son clue
Answer
Clue
Relevancy
niece
Clue
Your sister's son's sister
Your sister's son's sister, to you
Your brother's son's sister
Definition
a daughter of one's brother of sister
tia
Clue
"Sister, Sister" sister
Sister of "Sister, Sister"
nephew
Clue
Your sister's son
Definition
the son of one's brother or sister
nieces
Clue
Your sister's son's sisters
Definition
NIECE, a daughter of one's brother of sister
reefermadness
Clue
1930s anti-marijuana propaganda film that ends with the principal of a school saying, "The next tragedy may be that of your daughter...or your son...or yours or yours..." [points at the camera] "... o